منابع مشابه
Chance and the prepared mind in drug discovery
Chance and accidents play important roles in scientific discoveries, but they are not blind luck. Serendipity is not merely stumbling on things unsought for, it is the ability to see significances and find values in the things stumbled upon. Without this ability, accidents do not lead to discoveries, as Pasteur observed: “Chance favors the prepared mind.” What are the characteristics of a prepa...
متن کاملOn drug development, chance, and the prepared mind.
This CCR Focus section examines lessons learned in drug development, focusing on specific examples of agents or targets that have hit roadblocks during development. In some cases, the hurdles have been surmounted; others are still a work in progress. Much has been written about the need to increase the success rate of drugs transitioning from phase II to phase III trials; about half of the drug...
متن کاملA Chance Favors a Prepared Mind: Chance Discovery from Cognitive Psychology
A chance has two contrary aspects: suddenness as an accidental finding and gradualness as the result of a prepared mind. Such duality of chance discovery resembles the insight process treated by problem solving researches. In this paper, we focus on the insight process in human problem solving, present a broad overview of its suddenness and the gradualness, and introduce our experimental result...
متن کاملChance favors the prepared mind--from serendipity to rational drug design.
Accidental discoveries always played an important role in science, especially in the search for new drugs. Several examples of serendipitous findings, leading to therapeutically useful drugs, are presented and discussed. Captopril, an antihypertensive Angiotensin-converting enzyme inhibitor, was the first drug that could be derived from a structural model of a protein. Dorzolamide, a Carboanhyd...
متن کاملChance favors a prepared genome.
D uring evolution, all vertebrates have been exposed to multiple waves of crossspecies infection by retroviruses. A number of defensive strategies have developed, among them the spontaneous expression, throughout the body, of restriction factors, antiviral proteins that will bind to the capsid (CA) protein of incoming virions and interfere with virus replication (1). One example of such a prote...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2015
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2015.02.053